For a formula compound I, AR is preferably 5-tercbutil-3-metalansulfonilamino-2-methoxy-fenil; R1 is cyclo-c4-c6, may have 1-2n cyclopentadiene, may have monomer or substitute R7; R7 is tar of C1-C3, hydroxyl, C1-C3, amino, etc.; R2 h, halide, C1 tar; MES ch, N; t is link, C1-C4 or c10-c3 not replaced. N is 1-3 P is 0-3 The most popular compounds are: (5-terc-butil-3-metalansulfonilamino-2-methoxi-fenil) - 1-methyl-7 - [4 - (1-methyl-piperidin-4-carbon) - piperazin-1-ilmethyl] - 1h-indol-2-carboxilico;[5-terc-butil-2-methoxi-3 - (4-methyl-piperazin-1-ilmet) - fenil] - Amida del acido (s) - 1-meth-7 - [4 - (1-meth-pirrolidin-2-carboxil) - piperazin-1-ilmet] - 1h-indol-2-carboxillico; among others. A pharmaceutical composer was also mentioned These compounds are effective inhibitors of map quinasa p38 in the treatment of respiratory diseases.
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机译：对于式I化合物，AR优选为5-tercbutil-3-金属磺酰基氨基-2-甲氧基-苯腈; R1为环-c4-c6，可具有1-2n的环戊二烯，可具有单体或取代基R7; R 7是C 1 -C 3的焦油，羟基，C 1 -C 3，氨基等。 R 2 h，卤化物，C 1焦油; MES ch，N; t是链接，未替换C1-C4或c10-c3。 N是1-3 P是0-3最受欢迎的化合物是：（5-terc-butil-3-metalansulfonilamino-2-methoxi-fenil）-1-methyl-7-[4--（1-methyl-piperidin- 4-碳）-哌嗪-1-基甲基]-1h-吲哚-2-羧;（5-terc-butil-2-methoxi-3-（4-甲基-哌嗪-1-基）-fenil]-阿米达acido（s）-1-meth-7-[4--（1-meth-pirrolidin-2-carboxil）-piperazin-1-ilmet]-1h-indol-2-carboxillico;其中。还提到了药物组合物。这些化合物在呼吸道疾病的治疗中是map quinasa p38的有效抑制剂。
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