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SYNTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION
SYNTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION
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机译:参与环化反应的肾素抑制剂的合成
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摘要
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, wherein R, R 1 , and R' are as defined in the specification, or a salt thereof, and a compound of formula IV wherein R, R 1 , R 2 and R' are as defined in the specification, and processes of manufacturing these.
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