Procedure displacement chromatography and cation exchange cationic organic compounds for use as displacer compounds in the method of displacement chromatography cation exchange.

摘要

A displacement chromatography process, comprising: charging into a suitable stationary phase a mixture comprising one or more components to be separated; shifting at least one of the one or more components of the stationary phase by applying to the stationary phase a mixture comprising a displacer compound having the general formula (I): wherein: each group R1, R2, R3, R ' 1, R'2, R'3 and independently can be selected from alkyl, aryl, and aralkyl, and which can form a ring containing one or more quaternary nitrogens with one or more of R1 and R2, R1 and R'1, R1 and R4, R4 and R'4, or R4 and R5; each R4, R'4, R5 and R'5 independently may be selected from alkyl, aryl, aralkyl and - (CH2) a- (CHY) b (CH2) cN + R1R2R3An - wherein R1, R2 and R3 are as defined above; each Y independently may be selected from -H, -OH, -OR6, halo, alkyl, aryl and aralkyl, wherein -R6 may be alkyl or - (CH2) a- (CHOH) b- (CH2) cN + R1R2R3An -, wherein R1, R2 and R3 are as defined above, and one or more Y may be a group detectable by one or more electromagnetic methods; each q and z independently may be any integer from 0 to 6, with the proviso that q + z is equal to or less than 6; each a, b and c can independently be any integer from 0 to 2, with the proviso that the sum of a + b + c in any fragment is at least 1; and each An - independently may be one or more monovalent or polyvalent organic or inorganic as needed to obtain a neutral compound anions.