PEPTIDE MODULATORS OF THE δPKC INTERACTION WITH THE D SUBUNIT OF F₁F_O ATP SYNTHASE/ATPASE AND USES THEREOF

摘要

The present invention provides isolated or synthetic peptides derived from the d subunit of mammalian F₁ F_o ATP synthase (dF₁ F_o) protein for the purposes of tissue protection and improved energy production following acute injury from ischemia/reperfusion or other toxic insults, or in chronic diseases such as diabetes and cancer. The major focus of the patent protection will be 2 peptides comprising an amino acid sequence having at least 75% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2 and pharmaceutical compositions thereof. However, additional peptide sequences within the dF₁F_o protein may also have efficacies in these disease states and we therefore include all peptides shown in the Figures of this application (combined with the HIV-Tat protein transduction, COIV mitochondrial targeting and Flag domains) for their efficacies in these conditions.