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FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF REGULATORY ELEMENTS IN UNTRANSLATED REGIONS OF GENES
FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF REGULATORY ELEMENTS IN UNTRANSLATED REGIONS OF GENES
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机译:基因未转化区域中调节性元素的高通量表征功能矩阵
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摘要
This invention provides libraries of expression constructs having different untranslated regions (UTR) from a genome. The expression constructs include transcription regulatory sequences operably linked with a reporter gene and a 5' UTR, a 3' UTR or both, wherein the translation of the reporter gene is under the regulatory control of control regions in the UTR sequence. The libraries of this invention are useful for determining the impact of regulatory sequences in the UTRs on translation of open reading frames under a variety of conditions, such as different cellular environments.
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