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A METHOD FOR DETECTING IGF1R/CHR 15 CIRCULATING TUMOR CELLS USING FISH
A METHOD FOR DETECTING IGF1R/CHR 15 CIRCULATING TUMOR CELLS USING FISH
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机译:用鱼检测IGF1R / CHR 15循环肿瘤细胞的方法
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摘要
The present invention describes methods and probe composition for an automated FISH assay of a blood sample containing circulating tumor cells expressing the IGF-1R gene. The assay provides genetic analysis of suspect circulating tumor cells that have been identified after immunomagnetic selection and fluorescent labeling. Using unique, repeat-free probes to the IGF-1R locus and a chromosome 15 reference probe, cell lines expressing an aberrant number of IGF-1R and Chr 15 signals were detected, including one cell line with a low level of IGF-1R amplification. The ability to directly examine the genetic profile of IGF-1R on circulating tumor cells may provide an automated means for assessing disease and patient response to therapy.
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