Solubilized topoisomerase poisons

摘要

The invention provides compounds of formula (I) wherein A, B, W, Y, Z and R₁ have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.