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IN VITRO METHOD FOR INDUCING CYTOTOXIC T CELLS USING TH1 CELLS AND DENDRITIC CELLS
IN VITRO METHOD FOR INDUCING CYTOTOXIC T CELLS USING TH1 CELLS AND DENDRITIC CELLS
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机译:使用TH1细胞和树突状细胞体外诱导细胞毒性T细胞的体外方法
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摘要
PURPOSE: An in vitro method for inducing cytotoxic Th1 cells which express CXCR3+CCR4- and dendritic cells is provided to be applied to adoptive T cell immunotherapy.;CONSTITUTION: A composition for maturing dendritic cells contains Th1 cells which express CXCR3high/CCR4low. The dendritic cells are matured by culturing the Th1 cells and immature dendritic cells. A pharmaceutical composition for treating tumor or viral diseases contains the tumor or viral antigen-sensitized dendritic cells; and the Th1 cells. The tumor antigen is Wilm's Tumor antigen 1 (WT-1) peptide with an amino acid sequence of sequence number 1. The viral antigen is cytomegalovirus(CMV) peptide with an amino acid sequence of sequence number 2.;COPYRIGHT KIPO 2011
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