MARKER GENE FOR DETECTING HUMAN TOXICITY-INDUCING DRUG AND A METHOD FOR DETECTING TOXICITY-INDUCING DRUG USING THE SAME

摘要

PURPOSE: A method for detecting toxicity-inducing drug is provided to monitor and determine drugs or chemicals having toxicity.;CONSTITUTION: A DNA microarray chip for detecting human toxicity-inducing drug contains: entire nucleic acid sequence of gene groups 1 to 6; an oligonucleotide which is a fragment having 18-30 nucleic acid sequences; or complementary stand thereof. A method for detecting human toxicity-inducing drug comprises: a step of treating a test compound to human cell line; a step of isolating RNA from an test compound-treated experimental group and a control group; a step of synthesizing the RNAs into cDNA and labeling with different fluorescence; a step of hybridizing with a DNA microarray; a step of analyzing the DNA microarray chip; and a step of comparing expression level between the control group and experimental group.;COPYRIGHT KIPO 2011