COMPOSITION FOR WHITENING OF THE SKIN COMPRISING THIOSEMICARBAZONE DERIVATIVES

摘要

The present invention relates to a composition for skin whitening containing a thiosemicarbazone derivative of the formula (1) having excellent whitening activity as an active ingredient. [Formula 1] In Chemical Formula 1, R ₁ and R ₃ are each independently hydrogen or C ₁ -C ₆ alkyl, R ₂ is hydrogen, cyclohexyl, phenyl, benzyl, or naphthyl with or without substituents, said substituents being selected from the group consisting of C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, and halogen, R ₄ is cyclohexyl, thiophenyl, phenyl, benzyl, or naphthyl with or without substituents, said substituents being C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, halogen, and C ₁ -C ₆ alkyl Selected from the group consisting of amines, R ₅ is hydrogen, C ₁ -C ₆ alkyl, or phenyl, Alternatively, R ₄ and R ₅ may be bonded to each other to form a ring (except when R _1, R ₂ , R ₃ and R ₅ are all hydrogen and R ₄ is phenyl).