2-Sulfanyl-benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition containing the same as an active ingredient for the prevention and treatment of the diseases induced by the overactivation of PolyADP-ribosepolymerase-1

摘要

The present invention represented by the general formula (1) 2-sulfanyl-benzimidazole-4-carboxamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and containing the same as an active ingredient, a poly (ADP- ribose) polymerase -1 (PARP-1) a pharmaceutical for the prevention or treatment of diseases which are caused by actively relates to a composition, the present invention are the derivatives and to consume a large amount of ATP upon activation which results in cell damage and cell death enzyme PARP-1 strongly inhibited the bar, myocardial infarction, angina pectoris, arrhythmia, heart failure, stroke, , a brain trauma or ischemic disease and Parkinson's disease, including renal failure, Alzheimer's disease or preventing or treating neurodegenerative disorders, including the use of multiple sclerosis, also using a surgical therapy and thrombolytic agents, including coronary artery bypass surgery or percutaneous coronary angioplasty may be useful as cardioprotective medication use during treatment, such as reperfusion therapy. ; [Formula 1] ; (wherein, R ¹ , ^{R 2 , X and n are as defined in the specification same.)}