MEANS ON THE BASIS OF THE IMMUNOGLOBULIN CONSTANT AREA, BINDING FC-RECEPTOR

摘要

1. Cluster stradomer containing two or more multimerized cluster stradomeric units, where each of these cluster stradomeric units contains at least one multimerizing region and at least one Fc domain, where multimerizing regions of two or more cluster stradomeric units form a cluster during multimerization a stradomer, and where the cluster stradomer specifically binds to the Fc receptor. ! 2. The cluster stradomer according to claim 1, where each of the at least one multimerizing region is independently selected from the group consisting of the hinge region of IgG2 and CH2 of the IgE domain, leucine zipper, isoleucine zipper and zinc finger. ! 3. Cluster stradomer according to claim 1, where the multimerizing region is the hinge region of IgG2. ! 4. The cluster stradomer according to claim 3, where the hinge region of IgG2 is located at the C-end of the specified at least one Fc domain. !5. Cluster stradomer according to claim 1, where each of the at least one Fc domain is independently selected from the group consisting of the hinge region of IgG1, the hinge region of IgG3, CH2 domain of IgG1, CH2 domain of IgG3, CH3 domain of IgG3, CH3 domain of IgG1, CH3 domain of IgG3 and combinations of the listed. ! 6. The cluster stradomer according to claim 1, where the stradomer monomer contains two Fc domains, where two Fc domains are CH2 IgG1 and CH3 IgG1, and where the multimerizing region is a hinge region of IgG2. ! 7. The cluster stradomer according to claim 1, where each cluster stradomeric unit specifically binds to at least one FcR, preferably one or more FcγRI, FcγRII, FcγRIII, human FcγRIV or their non-human equivalents. ! 8. A body containing two or more related monomers of a stradomer, where each