HYBRID CELL STRAIN OF Mus. musculus ANIMALS - PRODUCER OF MONOCLONAL IVERMECTIN ANTIBODIES, AND MONOCLONAL IVERMECTIN ANTIBODIES

摘要

FIELD: medicine.;SUBSTANCE: strain 4C6 is produced received by cell fusion of line SP2/0 murine myeloma and splenocytes of Balb/c mice immunised by intraperitoneal introduction of the purified ivermectin-BsA conjugate, and is deposited in the Collection of Vertebrates Finite Body Cells of State Institution D.I.Ivanovsky Research Virology Institute of the Russian Academy of Medical Science, No. 05/09. The hybridoma strain 4C6 synthesizes class IgGl monoclonal antibodies (MCA) specifically reacting in a competitive solid-phase enzyme immunoassay (EIA) with a group of compounds referred to a group of avermectins: ivermectin, avermectin, abamectin, aversectin.;EFFECT: use of MCA 4C6 as an immune detector allows the high sensitive and specific quantitative evaluation of avermectins in biological fluids and tissues.;2 cl, 1 dwg, 2 tbl, 3 ex