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peptides and polypeptides with improved stability, for the regeneration of the nervous system are
peptides and polypeptides with improved stability, for the regeneration of the nervous system are
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机译:用于神经系统再生的稳定性提高的肽和多肽
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摘要
Type 1 thrombospondin repeat peptides (I) are new. Peptides (I) comprising SEQ ID NO:10 are new, except for the peptide with SEQ ID NO:1. X2-Gly-Trp-Ser-Ser-X1-Ser-X3 (SEQ ID NO:10) Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser-Cys-Gly (SEQ ID NO:1) X1 : Cys or Abu; X2 : Trp-Ser, Trp-Abu or Leu-Nal2-Ser; X3 : Arg-Ser, Arg-Abu or Lys(iPr)-Ser. ACTIVITY : Neuroprotective. MECHANISM OF ACTION : Nerve cell growth stimulant. B104 neuroblastoma cells cultured for 3 days in a medium containing the peptide Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser (SEQ ID NO:2) had a maximum neurite length of 0.196 mm, comprared with 0.148 mm for control cultures.
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机译:1型血小板反应蛋白重复肽(I)是新的。包含SEQ ID NO:10的肽(I)是新的,除了具有SEQ ID NO:1的肽。 X2-Gly-Trp-Ser-Ser-X1-Ser-X3(SEQ ID NO:10)Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser-Cys-Gly(SEQ ID NO: 1)X1:半胱氨酸或阿布; X2:Trp-Ser,Trp-Abu或Leu-Nal2-Ser; X3:Arg-Ser,Arg-Abu或Lys(iPr)-Ser。活动:具有神经保护作用。作用机理:神经细胞生长刺激剂。在含有肽Trp-Ser-Gly-Trp-Ser-Cys-Ser-Arg-Ser(SEQ ID NO:2)的培养基中培养3天的B104神经母细胞瘤细胞的最大神经突长度为0.196 mm,与对照培养物为0.148毫米。
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