NOVEL PEPTIDES AND POLYPEPTIDES WITH IMPROVED STABILITY USEFUL IN REGENERATION OF THE NERVOUS SYSTEM

摘要

Type 1 thrombospondin repeat peptides (I) are new. Peptides (I) comprising SEQ ID NO:10 are new, except for the peptide with SEQ ID NO:1. X2-Gly-Trp-Ser-Ser-X1-Ser-X3 (SEQ ID NO:10) Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser-Cys-Gly (SEQ ID NO:1) X1 : Cys or Abu; X2 : Trp-Ser, Trp-Abu or Leu-Nal2-Ser; X3 : Arg-Ser, Arg-Abu or Lys(iPr)-Ser. ACTIVITY : Neuroprotective. MECHANISM OF ACTION : Nerve cell growth stimulant. B104 neuroblastoma cells cultured for 3 days in a medium containing the peptide Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser (SEQ ID NO:2) had a maximum neurite length of 0.196 mm, comprared with 0.148 mm for control cultures.