N- (hetero) aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo 2,3-d pyrimidine and pyrrol-3-yl-pyrrolo 2,3-d pyrimidine as Janus kinase inhibitors

摘要

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.