Pharmaceutical composition for treating bone disease containing a protein containing Frizzled1, Frizzled2 or Frizzled7 extracellular cysteine-rich domain

摘要

The present invention relates to an extracellular cysteine-rich domain having an effect of increasing bone mass, bone density and / or bone strength derived from a Frizzled receptor selected from the group consisting of Frizzled1, Frizzled2 and Frizzled7 derived from mammals, or an amino acid of the domain A protein having a sequence identity of 85% or more to the sequence and having a bone mass, bone density and / or a bone strength increasing action, or a vector containing a nucleic acid encoding the protein, The present invention relates to a pharmaceutical composition for treating bone diseases, which is contained as an active ingredient.