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METHOD FOR SCREENING NEW DRUG CANDIDATE INHIBITING TARGET PROTEIN-PROTEIN INTERACTION FOR DEVELOPMENT OF FIRST-IN-CLASS DRUG
METHOD FOR SCREENING NEW DRUG CANDIDATE INHIBITING TARGET PROTEIN-PROTEIN INTERACTION FOR DEVELOPMENT OF FIRST-IN-CLASS DRUG
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机译:筛选新型候选药物抑制靶蛋白与蛋白质相互作用以开发同类药物的方法
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摘要
The present invention relates to a method for screening a substance inhibiting protein-protein interactions, and more particularly to a method for screening a substance inhibiting protein-protein interactions, the method comprising using a protein chip having immobilized thereon spots comprising a mixture of a sol-gel material and a protein. According to the invention, a protein chip can be easily manufactured in a 96-well plate using a sol-gel material, whereby an inhibitor that inhibits protein-protein interactions can be easily screened from a library of natural substances.
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