The present invention relates to the substances that a kind of screening inhibits protein-protein interaction, this substance, more particularly, to for screening the substance for inhibiting protein-protein interaction, this substance migration protein chip carries out a small amount of mixed sols-gelatinous mass to it and protein is fixed. Protein chip is easily manufactured from 96-well plate sol-gel substances in the present invention, so that easily screening inhibits the substance of protein-protein interaction, this substance is from natural object library.
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