Heterocyclic inhibitors of the NS5A Protein encoded by hepatitis C virus (HCV), Pharmaceutical compositions containing same and Use thereof for treating HCV infections

摘要

Item 1: the characteristic of the compound is that it has a formula (1): or a salt that can be accepted from the drug, where x and X independently select ch, CR1 and N, y 'independently select ch, CR2 and N, provided that there are no more than two of X, X,E y'sean n; R1 and R2 were independent of formula group (2);Each R3 is selected independently of hydrogen, cyanogen and halogen; each R4 is selected independently of hydrogen and tar, and tar can choose to form a combined ring of three to five members and adjacent carbon atoms, In this case, one or two methyl groups can be selected to replace the ring; or R4 and carbon composed of one eleleno group; each R5 is independent of hydrogen and - C (or) R6 selection; each R6 is independent of alcox, hydrocarbon, arilalcoxi, arilalquilo, cyclopentadiene, isocyclohexane, isocyclohexane, isocyclohexane and isocyclohexane selection,(nrcrd) alquenilo y (nrcrd) rents each R7 and R8 as an option independent of hydrogen and hydrocarbon groups.