7-3,5-dihydroXI-2-(3-hydroxy-5-phenyl-pentyl-1-phenyl) -cyclopentanediol-N-ethyl-Hept-5-enamida (Diatomic Prost); Crystal Form I Conversion Method-Crystal Form II; Drug Synthesis; and Methods for the Treatment of Eye Hypertension and Glaucoma.

摘要

Crystal Form II of 7- [3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent 1-enyl) cyclopentyl] -N-ethyl-hept-5-enamide (bimatoprost); meacute; all to convert bimatroprost from crystalline form I to crystalline form II; pharmaceutical composition; and its use to treat ocular hypertension ./p