New method of obtaining the crystalline form V of agomelatine

摘要

Process for preparing crystalline form of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (or agomelatine) comprises dissolving a solution of agomelatine in one or two solvents miscible in all proportions, where the boiling temperature is less than 120[deg] C, and the solution is atomized in an atomizer. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.