INDOL-1 -YL ACETIC ACIDS AND ESTERS AND USE THEREOF IN THE PREPARATION OF AN AGENT FOR THE TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASES

摘要

Compounds of general formula (I) wherein R1, R2 , R3 and R4 are independently hydrogen, halo,C1-C6 alkyl, -O(C1-C6 alkyl), -CON(R11)2 , -SO11, -SO2R11, -SO2N(R11)2, -N(R11)2, -NR11COR11, -CO2R11, -COR11, -SR11, -OH, -NO2 or -CN; each R11 is independently hydrogen or C1 -C6 alkyl; R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached forrn a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl; R8 is an aromatic moiety optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, -O(C1-C6)alkyl, -CON(R11)2, -SOR11, -SO2R11 , -SO2N(R11)2, -N(R11)2, -NR11COR11, -CO2R11, -COR11, -SR11, -OH, -NO2 or -CN; wherein R11 is as defined above; R9 is hydrogen, or C1-C6 alkyl; provided that: R8 is not phenyl substituted with -COOH; when any two of R1, R2 , R3 and R4 are hydrogen, neither of the other two of R1, R2 , R3 and R4 is C3-C6 alkyl; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in the preparation of pharmaceuticals for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.