HCV NS-3 SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USES THEREOF IN THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS OR TREATMENT OF FLAVIVIRUS INFECTIONS SUCH AS HCV

摘要

Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.