FUSED COMPOUNDS CONTAINING AN UREIDO GROUP THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR ,FOR TREATING DISORDERS CAUSED BY VANILLOID RECEPTOR ACTIVITY AND PROCESS FOR THEIR PREPARATION

摘要

The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.