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TREATING NEUROTOXICITY ASSOCIATED WITH COMBINATIONS OF 5- FU OR ITS PRODRUGS AND DPD INHIBITORS
TREATING NEUROTOXICITY ASSOCIATED WITH COMBINATIONS OF 5- FU OR ITS PRODRUGS AND DPD INHIBITORS
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机译:治疗与5-FU或其前体药物和DPD抑制剂联合使用的神经毒性
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摘要
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme in both nervous and non-nervous tissues within the patient and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU generated from a prodrug is in substantial excess of DPD inhibitor in the patient.
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