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Identification and isolation of fetal cells and nucleic acids by using an antibody which binds an fetal nucleosome epitope associated with histone H3.1
Identification and isolation of fetal cells and nucleic acids by using an antibody which binds an fetal nucleosome epitope associated with histone H3.1
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机译:通过使用与组蛋白H3.1相关的胎儿核小体表位结合的抗体鉴定和分离胎儿细胞和核酸
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摘要
Disclosed is a method for detecting the presence of fetal nucleic acids in a biological sample comprising: contacting the biological sample with an antibody that specifically binds to a fetal nucleosome epitope, and detecting the binding of the antibody to a nucleosome in the biological sample, wherein specific binding of the antibody to a nucleosome is indicative of the presence of fetal nucleic acids; and wherein the biological sample is a cervical mucus, amniotic fluid, or chorionic villus sample. Further disclosed is a method for isolating nucleic acid of a fetus comprising: isolating nucleic acid from a biological sample obtained from a maternal host of the fetus using an antibody that specifically binds to a fetal nucleosome epitope, wherein the biological sample is cervical mucus, amniotic fluid, or chorionic villus sample.
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