A monoclonal antibody that specifically binds to human TYRP1 (SEQ ID NO. 28) and comprises a VH chain with the amino acid sequence: QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLDYWGQGTLVTVSS (SEQ ID NO: 14), a CDRL1 having the sequence RASQSVSSYLA (SEQ ID NO: 4), a CDRL2 having the sequence DASNRAT (SEQ ID NO: 5), and a CDRL3 having the sequence QQRSNWLMYT (SEQ ID NO: 6). The antibody can be used to treat malignant melanoma.
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机译：一种与人TYRP1（SEQ ID NO.28）特异性结合的单克隆抗体，它包含一条具有以下氨基酸序列的VH链：QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLYSWQDYS QYLTLS（具有以下序列：具有序列DASNRAT（SEQ ID NO：5）的CDRL2和具有序列QQRSNWLMYT（SEQ ID NO：6）的CDRL3。该抗体可用于治疗恶性黑色素瘤。
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