2,4-diamino-pirimidina N2, n4-clusters as derivatives of JAK3 inhibitors

摘要

Pyridine derivatives from formula (I), where x and y are each or, s, s (or),Among other things, ring a is arilo (C6-C10) or 5-10 member heteromorphism; ring R2 is h, re, Rb, and re is asphalt (C1-C6),Bicycle (c3-c8),ARILO (C6-C10)RA is, inter Alia, h, bitumen (C1-C6),5-15 members are heteromorphic; P is 0-4; Z1 and Z2 are ch, CR2 or N; R3 and R4 are h, alternative tar (C1-C6), etc.; R5 is halogen, CN, tar (C1-C6),NITRO, AMONG OTHERS. THEY ARE PREFERRED COMPOUNDS: N4- (1,3-DIMETILBENZIMIDAZOLIN-2-ON-5-IL) -N2 - ((4-METILSULFONILAMINO) FENIL) -5-FLUOROPIRIMIDINA-2,4-DIAMINA; 5- [2- (2,4-DIFLUORO-5-METOXI-PHENYLAMINE) -5-METHYL-PIRIMIDIN-4-ILAMINO] -3H-BENZOXAZOLE-2-ONA; 5- (2- (4- (1- (CICLOPROPILAMINO) ETIL) FENILAMINO) -5-METHYLPYRIMIDIN-4-ILAMINO) BENZO [d] OXAZOL-2 (3H) -ONE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF JAK KINASAS BEING USEFUL IN THE TREATMENT OF AN AUTOIMMUNE DISEASE MEDIATED BY T-CELLS, REJECTION TO ALOINJERTO TRANSPLANT