Pririmidine derivatives useful as selective inhibitors of JAK3 and / or JAK1

摘要

A compound of general formula (I), ** Formula **, or a stereoisomer, pharmaceutically acceptable salt or hydrate thereof, wherein R1 is halogen or C1-C6 alkyl; R2 is one or more substituents selected from the group consisting of hydrogen, hydroxy, cyano, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 alkylcarbonyl and C1-C6 alkyl amine; R3 is hydrogen or halogen; R4 is hydrogen or C1-C4 alkyl; X is NH, O, or S; Y is CO or S (O) 2; Z is a covalent bond, CH2 or (CH2) 2; n is an integer from 1 to 4; and ring A is a benzene ring, a pyridine ring or a piperidine ring.