17u00df - alkyl - 17th - Oxy - estratrienos

摘要

Refers to compounds derived from 17? - alkyl - 17? - Oxy - estratrienos of formula (i) where Hal is Fluorine or Chlorine; R1, R2 and R4 are each h, Fluorine, Chlorine or Bromine; R3 is H, alkyl (c1-c4) or alcanilo (c1-c4); R17 'is H, alkyl (c1-c4) or alcanilo (C1 - C4); R17' is alkyl (c1-c4), alquenilo (c2-c4) or alquinilo (c2-c4); or is alquileno (C1, C2 alquenileno (C13) - C13)Among others, V is methylene or - C (o) -; X is a link or alquileno (C1 - C3); and is alquileno (C5 - C8); E (C1 - C4) or Perfluoroalkyl phenyl substituted by Halogen or Cf3; R5 is H, alkyl (c1-c4), alquenilo (c2-c4), among others; r1 R6 h, or CH2 - C (o) - Where R1, R1 is H, alquenilo (C2 - C6), among others.Preferred compounds are: [5 - (11? Fluoro - 3.17? Dihydroxy - 17? - metilestra - 1,3,5 - (10) - triennium 2008-2010 7? IL) Pentyl] - (methyl) Amine (8,8,9,9,9 - pentafluorononil); 11. Fluoro - 17? - methyl - 7? - [5 - [(2R) - 2 - (7,7,8,8,8 - pentafluorooctil) - 1 - pirrolidinil) Pentyl] - 1,3,5 estra - (10) - 3:17 - Sledging? Diol; among others. It also relates to a Pharmaceutical composition.These compounds are antiestrogenic action being useful in the treatment of Hormone dependent Tumors, Diffuse alopecia, endometriosis