Compounds of N - phenyl - (piperazinil or homopiperazinil) - or - (bencensulfonamida bencensulfonil phenyl piperazine or homopiperazina as serotonin receptor modulators) 5 HT6

摘要

Referring to a homopiperazina piperazine Derivatives of formula (i) or (I '), where X is a link or N - R4, R1 is H or Methyl; R2 is H or Methyl; R IS h, alkyl C1 - C3, fluoride, among others; R4 is H, c1-c4 alkyl, cycloalkyl C3 - C4, among others; R5 is H, F, CL, c1-c2, among others; R6 h, F Or cl; n is 1 or 2.Sompuestos hydrochloride are preferred: N - (Difluoromethoxy) - phenyl) - 4 - methyl - 3 - (piperazin-1-yl bencensulfonamida hydrochloride -, 1 - [4 - (Difluoromethoxy bencensulfonil - 3 - methyl - 2 -) phenyl] - Piperazine hydrochloride N - 4 - phenyl - (Difluoromethoxy) - 4 - methyl - 3 - (piperazin-1-yl - bencensulfonamida, among others. It also relates to a Pharmaceutical composition.These compounds Act by modulating the HT6 5 - serotonin Receptors and are useful in the treatment of cognitive disorders such as Alzheimer's disease, such as schizophrenia, Personality Disorders, eating disorders such as anorexia, bulimia, among others