1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR

摘要

By the condensation of tryptamine with appropriate substituted benzalde-hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo-lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te-traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)whichexhibit specific binding with rat brain benzodiazepine receptor in vitro.