首页> 外文OA文献 >Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor

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Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor

机译：发现一系列2-苯基-N-（2-（吡咯烷-1-基）苯基）乙酰胺，作为调节KV7.2（KCNQ2）通道药理模式的新型分子开关：鉴定（S）-2-苯基-N-（2-（吡咯烷-1-基）苯基）丁酰胺（ML252）作为有效的脑渗透kV7.2通道抑制剂

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Yiu-Yin Cheung; Haibo Yu; Kaiping Xu; Beiyan Zou; Meng Wu; Owen B. McManus; Min Li; Craig W. Lindsley; Corey R. Hopkins;
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年度 2012
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1. Discovery of a series of 2-phenyl- N -(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K _v7.2 (KCNQ2) channel pharmacology: Identification of (S)-2-phenyl- N -(2-(pyrrolidin-1-yl) phenyl)butanamide (ML252) as a potent, brain penetrant K _v7.2 channel inhibitor [J] . Cheung Y.-Y., Yu H., Xu K., Journal of Medicinal Chemistry . 2012,第15期

机译：发现一系列2-苯基-N-（2-（吡咯烷基-1-基）苯基）乙酰胺作为调节K _v7.2（KCNQ2）通道药理模式的新型分子开关：（S）-2-的鉴定苯基-N-（2-（吡咯烷基-1-基）苯基）丁酰胺（ML252）作为有效的脑渗透剂K _v7.2通道抑制剂
2. Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia [J] . Liang Xiaofei, Wang Beilei, Chen Cheng, Journal of Medicinal Chemistry . 2019,第2期

机译：发现N-（4-（6-乙酰胺嘧啶-4-基氧基）苯基）-2-（2-（三氟甲基）苯基）乙酰胺（CHMFL-FLT3-335），作为有效的FMS样酪氨酸激酶3内部串联复制（ FLT3-ITD）突变选择性抑制剂用于急性髓性白血病
3. Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic alpha(v)beta(6) Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis [J] . Procopiou Panayiotis A., Anderson Niall A., Barrett John, Journal of Medicinal Chemistry . 2018,第18期

机译：发现（S）-3-（3-（3,5-二甲基-1H-吡唑-1-基）苯基）-4 - （（r）-3（2-（5,6,7,8-四氢 -1,8-萘啶-2-基）乙基）吡咯烷-1-基）丁酸，非肽α（v）β（6）整联蛋白抑制剂，用于吸入治疗特发性肺纤维化
4. Discovery of a Series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent Brain Penetrant Kv7.2 Channel Inhibitor [O] . Yiu-Yin Cheung, Haibo Yu, Kaiping Xu, -1

机译：发现一系列2-苯基-N-（2-（吡咯烷-1-基）苯基）乙酰胺作为调节KV7.2（KCNQ2）通道药理模式的新型分子开关：鉴定（S）-2-苯基-N-（2-（吡咯烷-1-基）苯基）丁酰胺（ML252）作为有效的脑渗透kV7.2通道抑制剂

Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor

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