首页>
外国专利>
nanovettore conjugated with tsh in the treatment of thyroid cancer
nanovettore conjugated with tsh in the treatment of thyroid cancer
展开▼
机译:纳维酮联合TSH治疗甲状腺癌
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a liposome comprising a PEG-PDP-TSH component, in particular a) 1,2-dipalmitoyl-sn-glycero-3-phosphocholine monohydrate, b) cholesterol, c) 1,2- distearoyl-sn-glycero-3-phosphoethanolamine and d) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[PDP(methoxypolyethylene glycol-2000)].Preferably, the liposome is in the form of small unilamellar vesicle and has nanometric size. The liposome of the invention can be loaded with at least one drug suitable for the treatment of a thyroid disease, in particular gemcitabine, and is suitable for the intracellular delivery of a substance to a cell expressing TSHR.Said liposome can be used for the preparation of a medicament for the treatment of a disease of thyroid gland, in particular thyroid neoplasia. The present invention also provides a pharmaceutical composition comprising the liposome, in particular for intravenous administration.
展开▼