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COMBINATIONS OF METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF SEARCH DISORDERS
COMBINATIONS OF METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF SEARCH DISORDERS
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机译:代谢型谷氨酸受体拮抗剂的组合及其在治疗疾病中的应用
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摘要
Methods are provided for treating disorders associated with mGlu receptors by simultaneously inhibiting at least two mGluRs belonging to at least two different groups. In one embodiment, there are provided methods for treating a disorder associated with mGlu receptors 2, 3, and 5, including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluRS. The disorders treated by the method include, for example, nicotine addiction, cocaine addiction, and depression.
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