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INTERLEUKIN 12P40 VARIANTS WITH IMPROVED STABILITY
INTERLEUKIN 12P40 VARIANTS WITH IMPROVED STABILITY
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机译:稳定性提高的白介素12P40变体
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摘要
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
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