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Methods of treating cancer using interleukin-12p40 variants having improved stability
Methods of treating cancer using interleukin-12p40 variants having improved stability
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机译:使用具有改善的稳定性的白介素12p40变体治疗癌症的方法
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摘要
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
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