PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN

摘要

The present invention refers to a process for preparing a compound of generalformula (A), wherein R is a radical of naproxen or bromonaproxen and R1-R12are hydrogen or alkyl groups, m, n, o, q, r and s are each independently aninteger from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13oran aryl, heteroaryl group, said process comprising reacting a compound offormula (B) : R-COOZ wherein R is as defined above and Z is hydrogen or acation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium,tetralkylphosphonium, with a compound of formula (C), as reported in thedescription, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Yis a suitable leaving group.