SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENT ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY

摘要

Disclosed is the preparation and pharmaceutical use of substitutedarylalcanoic acid derivatives of Formula I, wherein ring A, ring B, Rl, R2,R3, R4, R5, X, Alkl, Alk2, Arl, and Ar2 are as defined in the specification.These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma,and RXRJPPARdelta heterodimers, are useful in the treatment and/or preventionof type 2 diabetes and associated metabolic syndrome such as hypertension,obesity, insulin resistance, hyperlipidemia, hyperglycemia,hypercholesterolemia, atherosclerosis, coronary artery disease, and othercardiovascular disorders with improved side effects profile commonlyassociated with conventional PPARgamma agonists.