RADIOISOTOPE LABELED FOLIC ACID CONJUGATE HUMAN SERUM ALBUMIN SPECIFIC TO TUMOR AND SENTINEL LYMPH NODE

摘要

The present invention relates to: radioisotope labeled folic acid conjugate human serum albumin specific to tumor and lymph tissues, and to a preparation method thereof; a disposable kit for images of a tumor and sentinel lymph node which comprises a mixture in which methylene diphosphonic acid, ascorbic acid and stannous chloride are added to folic acid conjugate thiol human serum albumin, and a preparation method of the disposable kit; and a composition for imaging tumor cells metastasized to a sentinel lymph node and comprising radioisotope labeled folic acid conjugate human serum albumin, and an imaging method. According to the present invention, useful effects are derived, of reducing the possibility of a false-negative, and providing a sentinel lymph node marker which further increases the accuracy of biopsies of sentinel lymph nodes because it has characteristics of an active marker specifically binding to a tumor as well as characteristics of a passive marker that remains in a lymph node for a long period of time.