PHARMACEUTICAL COMPOSITION CAPABLE OF TARGETED RELEASE OF TRACE ELEMENT, AND PREPARATION METHOD AND APPLICATION OF PHARMACEUTICAL COMPOSITION

摘要

A pharmaceutical composition having an effect of ultrasound targeted release of a trace element comprises hollow microspheres having a particle size of less than 10 μm at a concentration of higher than 1x10⁶/ml, at least one trace element at a concentration of less than or equal to ten times the physiological dose of a human body, and a pharmaceutically acceptable carrier or excipient. The trace element and the hollow microspheres exist in a manner of combination, and the hollow microspheres are prepared by a pharmaceutically acceptable film forming material.