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2-(R²-THIO)-10-3-(4-R1-PIPERAZIN-1-YL)PROPYL-10H-PHENOTHIAZINE FOR TREATING A β-AMYLOIDOPATHY OR AN ALPHA-SYNUCLEOPATHY, AND METHOD FOR THE DIAGNOSIS OR PREDIAGNOSIS THEREOF
2-(R²-THIO)-10-3-(4-R1-PIPERAZIN-1-YL)PROPYL-10H-PHENOTHIAZINE FOR TREATING A β-AMYLOIDOPATHY OR AN ALPHA-SYNUCLEOPATHY, AND METHOD FOR THE DIAGNOSIS OR PREDIAGNOSIS THEREOF
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机译：2-（R²-THIO）-10- [3-（4-R 1 -哌嗪-1-基）丙基] -10 H -吩嗪治疗β -淀粉样变性病或α-突触变性病，及其诊断或预诊断的方法
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摘要
The invention relates to 2-(R2-thio)-10-[3-(4-R1-piperazin-1-yl)propyl]-10H-phenothiazine according to general formula I, for treating a β-amyloidopathy or an α-synucleinopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter. The invention also relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances transported by the cerebral ABCC1 transporter.
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机译：本发明涉及2-（R 2 -硫代）-10- [3-（4-R 1 -哌嗪-1-基）丙基] -10 H -吩噻嗪，用于治疗伴有脑蛋白沉积和脑ABCC1转运蛋白活性降低的β-淀粉样变性病或α-突触核蛋白病。本发明还涉及诊断或预诊断伴有脑蛋白沉积和脑ABCC1转运蛋白活性降低的β-淀粉样变性病或α-核病的方法，或用于确定先证者患有此类疾病的风险的方法。疾病，先证者已经积累了由大脑ABCC1转运蛋白转运的物质。
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