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Full-length infectious cDNA clones of tick borne flavivirus
Full-length infectious cDNA clones of tick borne flavivirus
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机译:tick传黄病毒的全长感染性cDNA克隆
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摘要
Provided are full-length cDNA clones of Langat tick-borne flavivirus. In particular, the strains TP21 and E5 were obtained as full-length clones in single plasmids. Production of virions from cloned full length cDNA resulted in variants with reduced neurovirulence. Deletions in the 3' NCR also decreased neurovirulence. The affenuated variants of Langat tick-borne flavivirus may be used for vaccination purposes.
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