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Soild dispersion composition of pranlukast with improved bioavailability and the method of preparing the solid dispersion
Soild dispersion composition of pranlukast with improved bioavailability and the method of preparing the solid dispersion
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机译:具有提高的生物利用度的普仑司特固体分散体组合物和制备该固体分散体的方法
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摘要
Disclosed is a pranlukast solid dispersion composition with an improved and a method of manufacturing the same. More particularly, the present invention provides a pranlukast solid dispersion manufactured by a hot-melting process using a composition comprising pranlukast and at least one water-soluble polymer selected from the group consisting of polyvinylpyrrolidone vinylacetate copolymer, polyvinylpyrrolidone and polyvinylalcohol, which has greatly improved dissolution rate and bioavailability as compared to those prepared by the conventional spray-drying method, thus enabling to obtain the equivalent pharmaceutical effects with less amount of a drug.
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