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6+5 FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES
6+5 FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES
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机译:[6 + 5]融合自行车作为凝血酶拮抗剂,用于制备其的过程和包含该自行车的药物成分
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摘要
PURPOSE: A novel 6+5fused bicycle derivative and a pharmaceutical composition containing the same are provided to be used as a therapeutic agent for treating platelet aggregation, arteriosclerosis, vascular restenosis, blood clotting, and hypertension. CONSTITUTION: A novel 6+5fused bicycle derivative is denoted by chemical formula 1. A method for preparing the composition of chemical formula 1 comprises a step of reacting compounds of chemical formulas 2 and 3 or reacting compounds of chemical formulas 4 and 5. A PAR-1 antagonist composition contains the compound of chemical formula 1, pharmaceutically acceptable salt thereof, or pharmaceutically acceptable carrier.
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