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6+5 Fused bicycles as a thrombin antagonist, process for preparation thereof and pharmaceutical compositions containing the bicycles
6+5 Fused bicycles as a thrombin antagonist, process for preparation thereof and pharmaceutical compositions containing the bicycles
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机译:[6 + 5]融合自行车作为凝血酶拮抗剂,其制备方法和含有该自行车的药物组合物
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摘要
The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.
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