POSITIVELY CHARGED SUPERPARAMAGNETIC IRON OXIDE NANO-PARTICLE, A CONTRASTING AGENT USING THE SAME, AND A METHOD FOR MANUFACTURING THE SAME CAPABLE OF BEING USED AS EFFECTIVE CONTRASTING AGENT BASED ON A NONINVASIVE BIOLOGICAL IMAGE

摘要

PURPOSE: Positively charged superparamagnetic iron oxide nano-particle, a contrasting agent using the same, and a method for manufacturing the same are provided to improve the reproducibility of the iron oxide nano-particles by modifying the surface of the iron oxide nano-particles into polymer with a plurality of carboxylic groups.;CONSTITUTION: Positively charged superparamagnetic iron oxide nano-particles(10) are prepared. A polymer layer(12) is coated on the surfaces of the iron oxide nano-particles. Cationoid(14) is amide-bonded with the surface of the polymer layer. The polymer layer contains a plurality of carboxylic groups. A contrasting agent includes the superparamagnetic iron oxide nano-particles. A method for manufacturing the iron oxide nano-particles includes the following: the iron oxide nano-particles are prepared; the surfaces of the iron oxide nano-particles are coated with hydrophobic ligand; the hydrophobic ligand is substituted with polymer containing a plurality of carboxylic groups to form a hydrophilic polymer layer; and the carboxylic groups are reacted with amine-group containing the cationoid to form amide bonds.;COPYRIGHT KIPO 2012