POLYNUCLEOTIDE FOR DRUG METABOLISM PREDICTION INCLUDING SINGLE NUCLEOTIDE POLYMORPHISM OF NR1I2 GENE, A KIT AND A DRUG METABOLISM PREDICTION METHOD USING THEREOF

摘要

PURPOSE: A polynucleotide for drug metabolism prediction including single nucleotide polymorphism of a nr1i2 gene, a kit and a drug metabolism prediction method using thereof are provided to increase prediction probability and predict metabolic activation of bupropion according to process of rifampin by simple confirmation of genotype.;CONSTITUTION: A marker for predicting drug metabolism includes polynucleotide or complement thereof consisting of 8-200 continuous DNA sequences which respectively include 705th,34403rd, and 34823rd DNAs of polynucleotide which is represented by sequence number 1[SEQ ID NO:1]. The drug is bupropion. The drug metabolism is metabolism of the bupropion according to administration of rifampin. In the metabolism of bupropion, the bupropion is converted into hydroxybupropion. A kit for drug metabolism prediction includes a marker for the drug metabolism prediction. The drug metabolism prediction method comprises the following steps: obtaining nucleic acid sample material which includes NR1I2 gene; amplifying the polynucleotide which respectively includes 705th, 34403rd, and 34823rd DNAs of polynucleotide which is represented by sequence number 1; and determining genotype of 705th, 34403rd, and 34823rd DNAs of the polynucleotide which is represented by sequence number among the amplified polynucleotides.;COPYRIGHT KIPO 2012