PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCERS OR INHIBITION OF METASTASIS CONTAINING THE EXPRESSION OR ACTIVITY INHIBITORS OF MAP7D2, A NOVEL CANCER THERAPEUTIC TARGET

摘要

PURPOSE: A pharmaceutical composition containing an inhibitor of MAP7D2 expression or activation is provided to specifically overexpress MAP7D2 in kidney cancer, lung cancer, colon cancer, gastric cancer, and liver cancer tissue or cells. CONSTITUTION: A pharmaceutical composition for treating cancer or suppressing cancer metastasis contains an inhibitor of MAP7D2(MAP7 domain containing 2) protein expression or activation as an active ingredient. The MAP7D2 protein has an amino acid sequence of sequence number 1. The expression inhibitor is an antisense nucleotide, shRNA, or siRNA which complementarily bind to mRNA of MAP7D2 gene or ribozyme. The activation inhibitor is a compound, peptide, peptide mimetics, substrate analogue, aptamer, or antibody which complementarily binds to MAP7D2 protein.